-
Successful Daily Practices of Inclusion Teachers of Children with Down Syndrome
This study asked 230 regular education teachers about their educational practices in teaching students with Down syndrome within their mainstream classes. Teachers completed surveys that asked about background experience; preparation for inclusion and the transition process; classroom information (curriculum, class arrangement, therapies, and support services); and classroom management, instruction, and behavioral strategies. Analysis of data from 120 surveys indicated that most of the students with Down syndrome attended their neighborhood schools and received some type of related services. Most of the classes had an inclusion aide who also worked with other students. Teachers considered the inclusion of children with Down syndrome successful, though there was room for improvement. Teachers found the experience challenging, rewarding, and of great value to their general education students as well as the child with Down syndrome. They noted that extra work was necessary for preparing modified class assignments, homework, and evaluation procedures. The best learning arrangements were 1:1 and small group instruction, with peer tutors, computers, and team teaching was sometimes effective. Praise was the best behavior management strategy.
-
Results on the Tongue Protrusion in Downs, Following an Aspecific Antistress Drug Therapy. An Investigation on 88 Subjects
This investigation started from a consecutive series of 510 Down, selected with the exclusion of psychotic subjects. Among the 141 subjects = 27.65 % of the whole sample, who during the first consultation showed protrusion of their tongue, 88 of them (62.41%) had checked the result on this symptom following antistress drug therapy. The investigation on this subsample had the following features: as for gender they were 40 F + 48 M, with M/F = 120; the year of birth ranged between 1973 and 1993; the age at the first examination (in months) was average 40.42 +/- 35.39, with 6-183 range; distribution of the chromosomal anomalies: Four mosaicisms = 4.54%; 3 translocations = 3.41%; 80 standard trisomy 21 = 90.91%; 1 only clinical diagnosis = 1.14%; presence of the tongue protrusion: irregular in 4 = 4.65%; Frequent in 84 = 95.45%. A therapy with antistress drugs lasting average 14.73 months with range: 6-36, got the following results: 72 disappearances of the lingual protrusion = 81.82%; 8 irregular presence = 9.09%; Not varied frequent presence = 9.09%. The result is highly significant (p < 0.0001). The gender comparison suggests that there are not any meaningful differences both before and after drug therapy.
-
The Free Radicals Hypothesis in Causing Dementia: High Probability Refutation in Down's Syndrome Subjects
The reduced inactivation of oxygen's free radicals is one of the hypotheses put forward to account for the onset of Alzheimer's dementia. However scarce conclusive experimental data may be to support this theory regarding human species, its refutation has not been established with any certainty either. Subjects affected by Down's syndrome have a documented increase in the enzyme superoxide-dismutase-1 and about 30% increase in the enzyme glutathione-peroxidase, both scavengers of oxygen's free radicals. For this reason Down subjects, who are less prone to cerebral palsy from prematurity and low birthweight (Cocchi, 1987; Cocchi and Branchesi, 1988), should also show a retardation in the onset of dementia, compared to normal individuals. This is not however the case as on the contrary it is regularly found that Down subjects anticipate by an average of 15 years roughly the onset of an Alzheimer type of dementia.
-
PASS?
PASS? Say What? Vol. 2, No. 6, June 15, 2005, Future Planning for Families with Special Needs. Waddell & Reed, Inc.
-
Language Impairment Is Associated With Decreased Plasma Coenzyme Q10 Levels in Children With Down Syndrome
Objective: Coenzyme Q10 (CoQ10) is an important endogenous cofactor for oxidative phosphorylation and potent antioxidant. Children with Down syndrome (DS) have decreased plasma CoQ10 compared with healthy children. The current follow-up report describes a relationship between CoQ10 and language impairment in children with DS. Materials & Methods: Twenty-two children with trisomy 21 previously participated in a CoQ10 dosing study. In this post hoc analysis, baseline plasma CoQ10 and cholesterol test results from the dosing study [1] were related to language impairment. Preschool Language Score (PLS-3) results for 20 participants (10 males, mean 5.1 years, range 1.7-9.3 years) were collected from their clinical records (2 were missing). Data were stratified according to PLS-3, i.e. severe (PLS-3 <70) and mild-moderate (PLS-3 =70-84) language disorder groups. P-values =0.05 were considered significant. Results: Children with severe language disorders (n=14) have significantly lower cholesterol-adjusted CoQ10 levels than children with mild-moderate disorders (n=6), i.e. 0.19 vs. 0.25 umol CoQ10/mmol cholesterol, respectively (P=0.021, Mann Whitney U test). Also a weak correlation exists between CoQ10 levels and PLS-3 data (r=0.44, P=0.05). Conclusion: These preliminary findings suggest that language impairment in children with DS may be related to a CoQ10 deficiency. Because CoQ10 supplementation has been shown to provide functional and neuroprotective benefits in neurodegenerative diseases, we hypothesize that CoQ10 supplementation may improve language skills in some children with DS.
-
He Has Up Syndrome Not Down Syndrome
Book excerpt, p.48-50.
-
Down's Syndrome and Cancer
Down's syndrome is a genetic disorder that is caused by trisomy of chromosome 21. Individuals with Down's syndrome have an increase risk of leukemia (10-20 fold) and a decreased incidence of solid tumors. It has been speculated that the genes on chromosome 21 are responsible for this abnormal distribution of cancer. One of such genes is copper zinc superoxide dismutase which catalyzes the dismutation of superoxide into hydrogen peroxide. Endostatin, a potent angiogenesis inhibitor, is also upregulated by trisomy 21. The paper discusses the possible role of these two genes in the occurrence of cancer in Down's syndrome subjects.
-
Puttin' For Down Syndrome
The Puttin' For Down Syndrome golf tournament raised $2,500 for the Down Syndrome Association and $2,500 for the Down Syndrome Center at St. Louis Children's Hospital. But the October event in Swansea, Ill., was priceless to a special group of kids who attended their own clinic during the tourney. More than a dozen children and young adults with Down syndrome took part in the clinic, courtesy of golf pro Dan Polites with the Clinton Hills Golf Club. Along with memories of perfecting their signature swing, each player got to take home his or her own personalized golf club.
-
Visioning?
Visioning? Say What? Vol. 2, No. 7, July-August, 2005, Future Planning for Families with Special Needs. Waddell & Reed, Inc.
-
Exploring the Neurobiological Basis for Cognitive Problems in Down Syndrome
The hypothesis that guides our work is that each cognitive abnormality in DS is due directly or indirectly to increased expression of a specific gene(s) on chromosome 21. By discovering the responsible gene(s) it may be possible to prevent or rescue the defect. Our studies place a particular emphasis on hippocampal circuits that mediate learning and memory. We examine mouse models of DS and define changes that recapitulate those seen in DS. The Ts65Dn mouse model has a third copy of a portion of mouse chromosome 16 which is very similar to human chromosome 21 in that it contains an extra copy of about 140 homologous genes. Importantly, these mice show abnormalities in cognitive tasks mediated by hippocampus, including defects in spatial learning and memory.
-
Exploring the Neurobiological Basis for Cognitive Problems in Down Syndrome. Commentary
I would like to extend my thanks to Dr. Mobley's Stanford University Down Syndrome Research team. They are moving research into uncharted territory and uncovering positive discoveries for more treatment options. (Hippocampal Long-Term Potentiation Suppressed by Increased Inhibition in the Ts65Dn Mouse, a Genetic Model of Down Syndrome. J Neurosci. 2004 Sep 15; 24(37):8153-60) This is the most exciting time in the history of DS research with the advent of a genetically engineered DS mouse, this means to add or subtract a gene or genes to/from that mouse.
-
The Five Goodbyes. Mothering My Child with Down Syndrome
Book excerpts: Prologue and Molly's First Day of Kindergarten.
-
Taste of the Tier helps combat cystic fibrosis
I am always happy to tell people about an opportunity to have a great night out while helping a worthy cause -- this week it's Taste of the Tier, the annual benefit for the Cystic Fibrosis Foundation of Central ...
Comment
-
Robbinsdale district educations lead the way on an upward climb
Taking steps toward a cure for cystic fibrosis has led to a friendship between two teachers with poignant stories, as well as the involvement of hundreds of their students.
Comment
-
CF Raccoon Hunt Set This Weekend
The annual Raccoon Hunt and Dog Show benefiting the Cystic Fibrosis Foundation is set for Friday and Saturday in Atlanta, said Ashley Jamison, special events coordinator for the foundation's Tyler office.
Comment
-
Norwich man receives award for advocacy of cystic fibrosis patients
NORWICH -- By his own account, Hal Soloff has been many things in his life; teacher, attorney, political activist and world-traveler, just to name a few.
Comment
-
Cystic Fibrosis - Topix.net
News on Cystic Fibrosis continually updated from thousands of sources around the net.
-
Cystic Fibrosis - Topix.net
News on Cystic Fibrosis continually updated from thousands of sources around the net.
-
A night at The Bluebird
Tammy Cochran brought a taste of Nashville night life to the Geneva Veterans of Foreign Wars hall Friday night.
Comment
-
Copernicus Therapeutics helps Parkinson's researcher
Categories: Breaking News University of Kentucky researcher David Yurek is using technology from Copernicus Therapeutics Inc.
Comment
-
Phase II Cystic Fibrosis Study Closes Enrollment
SYDNEY, Australia, March 1 /Xinhua-PRNewswire-FirstCall/ -- Pharmaxis Ltd Array The study has entered 25 subjects.
Comment
-
Cystic Fibrosis Leads Mother To Write Children's Book
Cystic fibrosis is an inherited disease and until the 1980s, most deaths occurred in children and teenagers.
Comment
-
Cystic Fibrosis Program at New York-Presbyterian Among Nation's Best
The Cystic Fibrosis Program at NewYork-Presbyterian Hospital/Columbia University Medical Center and Morgan Stanley Children's Hospital of NewYork-Presbyterian is among the nation's best, according to an ...
Comment
|
